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Welcome to Promoter Analysis Tools (PAtools). This site offers an computational environment to analyse promoter regions, generate consensus to polimerase binding sites, and predict putative DNA-promoters in sequences upstream genes in bacterial genomes. We take as model the E.coli K12 genome to make our predictions supported on the wide conservation of sigma70 factors among bacterial genomes. However, we offer the tool "Make Matrices" to create ad-hoc sensors for a given genome as long as the user provides a set of known promoter for that genome.
Escherichia coli K12 predictions
The analysis of the known E.coli K12 polimerase binding site and the methodology to predict new promoter sites is showed in the following chart.
Other Genomes Predictions.
Based on our analysis of primary sigmas in other genomes, we selected a set of genomes which showed a pattern of abundance of promoter-like signal similar to that of E. coli K12. The strategy to predict promoters in those genomes is showed in the following chart.